<I>TNF-α</I> gene expression in immune cells of patients with psoriasis and psoriatic arthritis

Introduction . Psoriatic disease is a heterogeneous inflammatory with different clinical manifestations, including plaque psoriasis and psoriatic arthritis. It has been shown that elevated levels of TNF- α are observed in both arthritis psoriasis. Studying the gene expression pattern can help differential diagnosis between The objective to study blood mononuclear cells patients for possible these two diseases. Materials methods Mononuclear were isolated from peripheral 31 psoriasis, 45 20 healthy controls. level was analysed using real-time PCR method. Results discussion As result comparison, found be 179 times higher than volunteers. also significantly (106 times) people. We managed identify significant difference Conclusions Patients terms close condition A high TNF-α become marker joint injury signal revise therapeutic approach particular patient.